Immune Regulation of Chlamydia trachomatis Infections of the Female Genital Tract
نویسندگان
چکیده
Tubal infertility and reproductive damage, preeclampsia and preterm births may potentially occur in many of the 50 million women who are annually infected with Chlamydia trachoma‐ tis [reviewed in 1; 24]. C.trachomatis infections of the genital tract are also reported to increase the risk of human immunodeficiency virus type 1(HIV-1) susceptibility and viral shedding in the genital tract either directly by pro-inflammatory signalling pathways or indirectly by their effects on genital epithelial cells [5]. A dramatic increase in the number of HIV-1 chemokine co-receptor CXCR4and CCR5-positive T cell targets has also been reported in the endocervix of C. trachomatis-positive women [6].
منابع مشابه
Immune Pathogenesis of Asymptomatic Chlamydia trachomatis Infections in the Female Genital Tract
Chlamydia trachomatis (CT) infections of the female genital tract, although frequently asymptomatic, are a major cause of fallopian-tube occlusion and infertility. Early stage pregnancy loss may also be due to an unsuspected and undetected CT infection. In vitro and in vivo studies have demonstrated that this organism can persist in the female genital tract in a form undetectable by culture. Th...
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Chlamydia (C.) trachomatis female genital tract infections usually remain asymptomatic and untreated. Therefore, an adequate immune response, rather than antibiotic treatment, is essential to clear the pathogen. Most women will effectively clear C. trachomatis infections, but some will have persistent C. trachomatis infections, which may ascend to the upper genital tract and increase the risk o...
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While ascension of Chlamydia trachomatis into the upper genital tract of women can cause pelvic inflammatory disease and Fallopian tube damage, most infections elicit no symptoms or overt upper genital tract pathology. Consistent with this asymptomatic clinical presentation, genital C. trachomatis infection of women generates robust TH2 immunity. As an animal model that modeled this response wo...
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Chlamydia trachomatis is the major cause of tubal occlusion, and is also associated with IVF failure and spontaneous abortion. These infections are asymptomatic in most individuals and can persist in the genital tract for long periods of time in a form resistant to immune destruction. A significant percentage of couples seeking treatment for infertility might, therefore, harbour C. trachomatis ...
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